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KMID : 0921620130430020145
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Journal of Bacteriology and Virology
2013 Volume.43 No. 2 p.145 ~ p.147
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PKR as a Regulator of Inflammasome Activation
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Manzoor Zahid
Koh Young-Sang
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Abstract
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Detection of pathogen by pattern recognition receptors leads to activation of inflammasome which plays a crucial role in immune system. The inflammasome regulates the release of cytokines, such as interleukin (IL)-1β, IL-18 and high-mobility group box 1 (HMGB1). Double-stranded RNA-dependent protein kinase (PKR) is a critical component of an inflammatory complex. Recently, the critical role of PKR was reported in regulation of multiple inflammasomes.
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KEYWORD
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Double-stranded RNA-dependent protein kinase, High-mobility group box 1, Inflammasome, Nod-like receptor family pyrin domain containing 3
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